JAVAHERB ®

Each tablet contains standard extract of Othosiphon aristatus (Java tea) ......... 250 mg

ACTIVE CONSTITUENTS:

The active principles for controlling blood sugar are dilterpenes. There are two groups of diterpenes: isopimarine-type (orthosiphones A and B, orthosiphols A, B, F, G, H and I) and pimarine-type (neoorthosiphols A and B). Other substances include saponins, alkaloids, tannin, essential oil, flavonoids, choline, betaine, organic acids and potassium salts.

In normoglycaemic rats, oral administration of an aqueous extract of O, aristatus (1g/kg) produces a significant decrease in blood glucose concentration compare with that in a control group.

In vitro and animal studies in rats have reported digretic activity of extract of O, aristatus and of flavonoids (sinensetin and tetramethoxyflavone). Oral administration of methylripariochromene A (100 mg/kg) has been shown to increase urinary volume in fasted rats for three hours after oral administration.

In stroke-prone, spontaneously hypertensive rats, subcutaneous administration of methylripario-chromene A (100 mg/kg) produced a continuous reduction in systolic blood pressure and a decrease in heart rate. It also suppressed agonist-induced contractions in the rat thoracic aorta and decreased the contractile force in isolated guinea pig atria without significantly affecting the beating (heart) rate.

A study involving 17 patients with type II Diabetes receiving 8 g or O. aristatus dried leaf in 250 ml boiled water for 30 mins, 3 times per day for 28 days was done in Department af Medical Research (Lower Myanmar). There was a statistically significant reduction of blood sugar level in these patients.

INDICATION:

For prevention and treatment of type II Diabetes mellitus

DOSAGE: (Adult)

For prevention - one tablet daily before dinner

For treatment - one to two tablets two times daily half an hour before meal.

CONTRAIDICATION:

Pregnancy and lactating mothers

60 tablets per bottle

A/U: 60's 

Remark: 10.4